Prospective Investigation of Nanoplastic Accumulation in Healthy Subjects, Autoimmune Diseases, Hematological Malignancies, Lung Cancer, and Murine Models

• DOI: 10.31219/osf.io/ey2sp
• Publication Date: 2024-06-27T20:47:43Z
• Authors: Roser Salvia; Manel Cañaveras; Laura G. Rico; Ana Drozdowskyj; Mike D. Ward; Rebeca Jurado; Laia Gómez-Muñoz; Marta Vives-Pi; Eva Martinez-Caceres; Jordi Petriz
• Keywords: Medical Sciences; mice; QH301-705.5; detection; QD415-436; Microbiology; Biochemistry; 01 natural sciences; Mice; Accumulation; Medicine and Health Sciences; Nanotechnology; Flow cytometry; human; Biology (General); Biology; 0105 earth and related environmental sciences; flow cytometry; Life Sciences; QR1-502; nanoplastics; Detection; Animal Sciences; Nanoplastics; accumulation; Nanocytometry; Human

Nanoplastics (NPs) and microplastics (MPs) are an emerging threat to global health. They negatively impact ecosystems and many physiological processes, causing alterations in xenobiotic metabolism, nutrient uptake, energy metabolism, or cytotoxicity. In humans, we are beginning to analyze these plastics for the mechanisms by which they enter the organism, accumulate and diffuse, and for their pathogenic potential. NP accumulation has been demonstrated in human tissues, such as blood or placenta, while in others it remains largely unstudied. In this work, we have detected NP accumulation in bronchoalveolar lavage fluids (BALF), cerebrospinal fluids (CSF), lymph nodes (LN), urine, pleural fluids (PF), ascitic fluids (AF) and peripheral blood (PB) by combining fluorescence and nanocytometry techniques. NP analysis has been compared with mouse animal models, suggesting that inhalation is the main route of NP accumulation.