Inflammatory Cytokine Response in Dengue Infected Female of Reproductive Age: Insight with Reference to a Pregnant Case

• DOI: 10.3126/jist.v29i2.65709
• Publication Date: 2025-02-05T09:22:23Z
• Authors: Ramanuj Rauniyar; Binod Manandhar; Satish Chandra Jha; Indu Bikram Joshi; Bimal Sharma Chalise; Paul K Wallace; William Telford; Krishna Das Manan...
• Keywords: Inflammatory response

Dengue treatment and management is challenging during the epidemic especially among risk groups to mitigate risks becomes even more complicated in absence of specific medicine vaccines. Till date, there are no research endeavours Nepal focusing on pregnant women with dengue evident gap concerning due overlapping clinical hematological manifestations physiological changes gestation. The study comprises clinically diagnosed one positive female, five female patients Sukraraj Tropical Infectious Disease Hospital (STIDH), Kathmandu healthy volunteers same reproductive age. investigates six different inflammatory cytokines; IL-1β, IL-6, IL-8, IL-10, IL-12p70 TNF levels plasma were quantified using Cytometric Bead Array. Cytokine profiles blood parameters statistically analyzed confidence intervals 93.75% as permitted by sample size visualized box whisker plot a highlighted case. shows IL-6 IL-10 elevated cases compared while exceeding upper limit acute subject, underscoring heightened activity synchronous pregnancy infection. There significant reductions hemoglobin leukocyte counts case non-pregnant. These findings suggest cytokine modulations occur underscores importance these patterns provide insight into targeted therapeutic diagnostic strategies for vulnerable population.