Radiation dose delivered by 125I, 103Pd and 131Cs and dose enhancement by gold nanoparticle (GNP) solution in prostate brachytherapy: a comparative analysis by Monte Carlo simulation

• DOI: 10.31436/iiumej.v20i2.1136
• Publication Date: 2019-12-02T01:36:57Z
• Authors: Hamda Khan; Umair Aziz; Zafar Ullah Koreshi
• Keywords: Pulmonary and Respiratory Medicine; Brachytherapy Dose Calculation; Brachytherapy; Biomedical Engineering; Dual-Energy Computed Tomography; FOS: Medical engineering; prostate cancer therapy; medical; 01 natural sciences; Intensity-Modulated Radiotherapy; dose enhancement; Engineering; Dosimetry; Particle Therapy for Cancer Treatment; Health Sciences; 0103 physical sciences; Proton Therapy; FOS: Mathematics; Radiation Sensitization; Absorbed dose; Internal medicine; Cancer; Radiotherapy Physics and Technology; Radiation; Prostate cancer; Radiochemistry; Physics; Statistics; Prostate; monte carlo simulation; Optics; Engineering (General). Civil engineering (General); Materials science; Monte Carlo method; Radiation therapy; Chemistry; Physics and Astronomy; gold nanoparticles; Physical Sciences; Nuclear medicine; Medicine; TA1-2040; Radiology; Nanoparticle Radiosensitization; Mathematics

: The energy deposition and radiation dose from commonly used radioisotopes, 125I,103Pd, 131Cs, for brachytherapy of cancers is estimated using Monte Carlo (MC) simulations. To enhance the dose, gold nanoparticle (GNP) solutions are injected into tumor; this results in more effective shorter therapy duration. It thus important to estimate enhancement factor (DEF) achievable by a radioisotope. research presented paper focuses on comparative analysis radioisotopes. N-particle code MCNP5 was coupled photon-electron simulation transport emanating seeds radioisotopes implanted prostate at positions prescribed deliver doses tumor while protecting neighbouring vital organs such as rectum urethra. quantities tallied were (F6 tally) pulse heights (*F8 specified bins. deposited absorbed incorporating transformations during decay. subsequently GNP-tissue solution with concentration 25 mg Au/g tissue, modelled homogenous mixture. From simulations, it found that lifetime ~96 Gy 98 seeds, each 0.31 mCi, 125I; ~102 Gy, 115 1.4 103Pd, ~90 131Cs replacing 103Pd same initial activity. main advantage over 125I observed larger rate (~26 cGy/hr) delivered initially i.e. first few days which 1.5 5.7 times higher than 125I. 125I, increases ~245, ~130, ~187 respectively tissue. analysis, all three order, there advantages 131Cs; these further quantified.
 ABSTRAK: Pemendapan tenaga dan dos sinaran radiasi daripada radioisotop yang biasa digunakan, digunakan bagi terapibraki kanser dianggar menggunakan simulasi (MC). Bagi meningkatkan dos, larutan partikel nano emas telah disuntik ke dalam ini lebih memberi kesan mengurangkan masa terapi. Oleh itu, adalah penting menganggar faktor penggalak dapat dicapai dengan radioisotop. Kajian mengfokuskan pada analisis perbandingan menganggarkan radiasi, kod N-partikel pasangan foton-elektron pengangkutan pancaran radioaktif benih ditanam prostat posisi disebut mencetuskan penghantaran berkesan sel tumor. Dalam sama melindungi organ seperti rektum uretra. Kuantiti diselaras pemendapan (selaras F6) ketinggian denyut *F8) aras sebenar. Tenaga dienap serapan menggabungkan transformasi ketika susutan. Dos diserap kemudiannya dianggarkan tisu-GNP ketumpatan tisu prostat, dimodelkan sebagai campuran homogen. Daripada simulasi, dapatan kajian menunjukkan sebanyak benih, setiap satu dari menggantikan pemulaan aktiviti sama. Keistimewaan utama atas dilihat kadar besar dikeluarkan pemulaannya iaitu beberapa hari pertama kali tinggi bertambah kepada masing-masing tisu. Hasil penyerapan seumur hidup ketiga-ketiga aturan sama, keistimewaan akan terus diuji depan diukur kuantitinya.