Concurrent hepatitis B infection and IgA nephropathy in a patient with a history of malignant melanoma

• DOI: 10.31450/ukrjnd.1(85).2025.01
• Publication Date: 2025-03-03T10:32:21Z
• Authors: Gülsüm Ceren Terz...; Alper Alp; Mürşide Gülay Örg...; Ferda Bacaksızlar...; Dilek Gibyeli Genek; Bülent Huddam
• Keywords: Hepatitis B

IgA nephropathy (IgAN) is an immune complex-mediated glomerulonephritis characterized by the deposition of IgA-dominant complexes in mesangium, leading to mesangial proliferation and subsequent renal injury. Clinically, IgAN often manifests as episodic macroscopic hematuria following upper respiratory tract or gastrointestinal infections. Disease progression variable, with 20–50% patients advancing end-stage disease within 10–20 years diagnosis. Although primarily idiopathic, it may also occur secondary systemic conditions such Henoch-Schönlein purpura, HIV infection, toxoplasmosis, ankylosing spondylitis, liver cirrhosis. Less commonly, can be associated hepatitis B virus (HBV) infection manifest a paraneoplastic phenomenon. Here, we report unique case clinical presentation successful treatment concurrent HBV patient history malignant melanoma. To our knowledge, this first documented which these three (IgAN, melanoma) coexist single patient.