Potential Anti-Inflammatory and Growth Inhibitory Effect of Cyrtopodion scabrum Extract on Colon Cancer; An in vivo Study

• DOI: 10.31557/apjcp.2023.24.4.1209
• Publication Date: 2023-04-28T20:03:37Z
• Authors: Zahra Babaei; Ghazal Namavari; Fatemeh Khademi; Farhad Koohpeyma; Mojtaba Rashidi; S M Shafiee; Fatemeh Zal; Atefeh Seghatoleslam
• Keywords: Vascular Endothelial Growth Factor A; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Colonic Neoplasms; Anti-Inflammatory Agents; Animals; Female; Lizards; Fluorouracil; 3. Good health; Research Article

The use of complementary and/or alternative medicine to increase the efficacy and decrease side effects current cancer treatment is highly required. In this in-vivo study, we aimed investigate anti-tumor activity probable a natural treatment, Cyrtopodion scabrum extract (CsE), in model tumor bearing mice.We established 28 female CT26-tumor balb/c-mice model. We divided them randomly into four groups (n=7): Negative control received distilled water (DW) three were administered with 5-FU two different doses (300 600 mg/kg) gecko aqueous extract, respectively. changes volumes weights during after along blood cell counts; spleen thymus indices assessed groups. have also measured serum TNF-α, VEGF, AST, ALT GSH, as well physical activities experimental found that means both CsE treated significantly lower than untreated group (p<0.05). Serum TNF-α VEGF levels remarkably caused RBC count, WBC index, index , while maintained these quantities, no significant changes, compared group. AST not changed none control.Altogether, data suggest C. scabrum, an effective safe anti-cancer source, which could be used alternative/complementary for patients who suffer from colon cancer.