Pattern and Prevalence of Congenital Malformation and Genetic Disorders among Offspring of Consanguineous Parents in Quetta

• DOI: 10.31580/pjmls.v5i1.2470
• Publication Date: 2022-11-21T11:02:27Z
• Authors: Ambreen Ijaz; Maryam Muhammad Ali; Shubana Kausar; Khadija Saif; Masooma Mukhtar ...; Razia Muhammad T...; Palwasha Tariq; Tahir Hameed; Gul Makai Panezai; Muhammad Masood ...; Nosheen Rafique; Aasia Karim; Zuhra Bibi
• Keywords: Consanguineous Marriage; Cousin

This cross-sectional study was carried out to examine the pattern and prevalence of congenital malformation/ genetic disorders among offspring consanguineous marriages in Quetta, Pakistan. A survey conducted 105 married couples from different areas Quetta city. 89 were related as first cousins, followed by second cousin (n=16) third (n=6) couples. Consanguineous common women who illiterate (43.8%) unemployed (87.6%). Highest number child mortality (61.9%) abnormalities (32.1%) observed children marriages. The most malformation /genetic mental retardation (24.13%), diabetes (10.3%), deafness (6.8%) thalassemia (6.8%). Among all inter-related marriages, are at highest risk have babies with anomalies.