Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy

• DOI: 10.31661/jbpe.v9i3jun.655
• Publication Date: 2019-07-06T08:50:57Z
• Authors: A Mesbahi; N Rasouli; M Mohammadzadeh; B Nasiri Motlagh; H Ozan Tekin
• Keywords: Radiobiology

Purpose: In the current study, using different radiobiological models, tumor control probability (TCP) and normal tissue complication (NTCP) of radiotherapy plans were calculated for three-dimensional conformal radiation therapy (3D-CRT) intensity modulated (IMRT) prostate cancer.Methods Materials: 10 randomly selected among patients undergoing cancer. For each patient, 3D-CRT IMRT designed to deliver, on average 76 Gy 82 planning target volume, respectively. Using models including Poisson, equivalent uniform dose (EUD) Lyman-Kutcher-Burman (LKB), TCP NTCP critical organs bladder, rectum femoral heads.Results: provided significantly lower heads LKB EUD (p-value <0.05). The EUD-calculated cancer revealed no considerable improvement relative plans. However, TCPs by Poisson model dependent α/β, higher was seen α/β than 5.Conclusion: It can be concluded that superior in terms estimated studied organs. On other hand, mathematical quantitative outcome More clinical studies are suggested confirm accuracy models.