Effect of experimental subarachnoid hemorrhage on the adrenergic innervation of cerebral arteries

• DOI: 10.3171/jns.1980.53.4.0477
• Publication Date: 2009-05-07T15:42:21Z
• Authors: Ramiro D. Lobato; Jesús Marín; Mercedes Salaices; Javier Burgos; Fernando Rivilla; Antonio G. García
• Keywords: Male; Sympathetic Nervous System; Dopamine beta-Hydroxylase; Cerebral Arteries; Subarachnoid Hemorrhage; Denervation; Norepinephrine; 03 medical and health sciences; 0302 clinical medicine; Cats; Animals; Female

The effect of subarachnoid hemorrhage (SAH) on the adrenergic innervation cat cerebral arteries was analyzed. Intracisternal injections autologous blood reduced noradrenaline content from perivascular nerves. Dopamine beta-hydroxylase and uptake 3H-noradrenaline were also decreased. These changes returned to normal in a period 2 3 weeks after SAH. Superior cervical ganglionectomy intracisternal 6-hydroxydopamine these three parameters. It is suggested that SAH induces transient denervation might be involved production chronic vasospasm.