Interleukin-6 overexpression as a marker of malignancy in human gliomas

• DOI: 10.3171/jns.2001.94.1.0097
• Publication Date: 2009-05-13T17:41:45Z
• Authors: Christine Rolhion; Frédérique Penaul...; Jean-Louis Kémény; Jean-Jacques Lemaire; Christiane Jullien; Corinne Labit-Bou...; Françoise Finat-D...; Pierre Verrelle
• Keywords: Interleukin 8

Glioblastomas multiforme (GBMs) grow rapidly and are highly resistant to treatment compared with other glioma types grades. Consequently, it is of major interest identify markers aggressiveness in these tumors that could represent new therapeutic targets. Interleukin (IL)-6 frequently produced gliomas and, given its manifold properties, be considered as a candidate marker. Expression IL-6 may involved cell growth, resistance chemotherapy radiotherapy (via an antiapoptotic pathway), angiogenesis. This study was conducted test this hypotheses evaluate the suitability target GBMs.The authors studied relationship between level gene expression assessed using semiquantitative reverse transcription-polymerase chain reaction by determining various histological grades series 59 gliomas. It found GBMs displayed significantly higher than (p < 0.001). Immunohistochemical analysis revealed mainly malignant cells few vascular endothelial cells.It can inferred from findings related play central role GBM behavior. Interleukin-6, therefore, potential GBMs.