Comparison of Contrast Effect on the Cochlear Perilymph after Intratympanic and Intravenous Gadolinium Injection

• DOI: 10.3174/ajnr.a2821
• Publication Date: 2011-12-16T06:31:49Z
• Authors: M. Yamazaki; S. Naganawa; M. Tagaya; H. Kawai; M. Ikeda; M. Sone; M. Teranishi; H. Suzuki; T. Nakashima
• Keywords: Adult; Aged, 80 and over; Gadolinium DTPA; Male; Tympanic Membrane; Adolescent; Contrast Media; Reproducibility of Results; Perilymph; Injections, Intralesional; Middle Aged; Image Enhancement; Magnetic Resonance Imaging; Sensitivity and Specificity; Cochlea; 03 medical and health sciences; 0302 clinical medicine; Injections, Intravenous; Humans; Female; Meniere Disease; Aged

3D-FLAIR imaging 24 hours after intratympanic gadolinium injection (IT-method) or 4 hours after IV injection (IV-method) has been used to visualize the endolymphatic hydrops in Ménière disease. The purpose of this study was to compare the degree of perilymph enhancement with the 2 methods and the perilymph contrast-effect difference with the IV-method in both sides in patients with unilateral Ménière disease.Sixty-one patients with Ménière disease or sudden SNHL were included in this study. Thirty-nine patients who underwent the unilateral IT-method (Gd-DTPA was diluted 8-fold with saline) and 22 patients who underwent the IV-method (a double-dose of Gd-HP-DO3A; 0.4 mL/kg body weight [ie, 0.2 mmol/kg body weight]) at 3T were analyzed retrospectively. Regions of interest of the cochlear perilymph and the medulla oblongata were determined on each image, and the signal-intensity ratio between the 2 (CM ratio) was subsequently evaluated. The differences in the CM ratio between the 2 methods (Student t test) and the IV-method CM ratio between the affected and unaffected sides in patients with unilateral Ménière disease (paired t test) were evaluated.The IT-method CM ratio (2.98 ± 1.15, n = 39) was higher than the IV-method CM ratio (1.61 ± 0.60, n = 44; P < .001). In patients with unilateral Ménière disease who underwent the IV-method (n = 9), the CM ratio of the affected side (1.86 ± 0.74) was higher than that of the unaffected side (1.29 ± 0.31, P < .05).In general, the IT-method provides higher perilymph enhancement than the IV-method. In the patients with unilateral Ménière disease who underwent the IV-method, the affected side had a higher contrast effect.