Relationship betweenAPOEGenotype and Structural MRI Measures throughout Adulthood in the Study of Health in Pomerania Population-Based Cohort

• DOI: 10.3174/ajnr.a4805
• Publication Date: 2016-05-12T22:19:05Z
• Authors: M. Habes; J.B. Toledo; S.M. Resnick; J. Doshi; S. Van der Auwera; G. Erus; D. Janowitz; K. Hegenscheid; G. Homuth; H. Völzke; W. Hoffmann; H.J. Grabe; C. Davatzikos
• Keywords: Apolipoprotein E

<h3>BACKGROUND AND PURPOSE:</h3> The presence of the <i>apolipoprotein E</i> ε<i>4</i> allele is strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that carriers and noncarriers may already differ in imaging patterns midlife. therefore sought to identify effect genotype on brain atrophy across almost entire adult age span by using advanced MR imaging–based pattern analysis. <h3>MATERIALS METHODS:</h3> analyzed scans 1472 participants from Study Health Pomerania (22–90 years age). studied association among age, carrier status, atrophy, which was quantified 2 indices: Spatial Pattern Atrophy for Recognition Brain Aging (summarizing age-related atrophy) Abnormality Early Disease disease-like patterns), as well gray matter volumes several disease- E</i>–related ROIs (lateral frontal, lateral temporal, medial hippocampus). <h3>RESULTS:</h3> No significant found between status or indices linear regression models adjusted sex, education, including an interaction term age. <h3>CONCLUSIONS:</h3> Our study indicates measurable does not occur early adulthood midlife suggests such only more proximal onset clinical symptoms dementia.