Validation of a Hemodynamic Model for the Study of the Cerebral Venous Outflow System Using MR Imaging and Echo-Color Doppler Data

• DOI: 10.3174/ajnr.a4860
• Publication Date: 2016-07-22T02:02:54Z
• Authors: G. Gadda; A. Taibi; F. Sisini; M. Gambaccini; S.K. Sethi; D.T. Utriainen; E.M. Haacke; P. Zamboni; M. Ursino
• Keywords: Supine position

<h3>BACKGROUND AND PURPOSE:</h3> A comprehensive parameter model was developed to investigate correlations between cerebral hemodynamics and alterations in the extracranial venous circulation due posture changes and/or obstruction (stenosis). The purpose of this work validate simulation results by using MR imaging echo-color Doppler experimental blood flow data humans. <h3>MATERIALS METHODS:</h3> To outcomes, we used supine average arterial extracerebral flow, obtained phase-contrast from 49 individuals with stenosis acquisition plane at level disc second third vertebrae left internal jugular vein, 20 fifth sixth right 38 healthy controls without stenosis. Average a group 10 volunteers screened an technique were evaluate variations change. <h3>RESULTS:</h3> There excellent agreement simulated flows. Every CBF fell inside standard error corresponding value, as well most (extracranial head face, measured vertebrae) Simulations vertebral change upright also matched data. <h3>CONCLUSIONS:</h3> good means that can correctly reproduce main factors affecting could be study other types stenotic conditions not represented