Preradiotherapy MR Imaging: A Prospective Pilot Study of the Usefulness of Performing an MR Examination Shortly before Radiation Therapy in Patients with Glioblastoma

• DOI: 10.3174/ajnr.a4917
• Publication Date: 2016-09-08T22:23:41Z
• Authors: C. Majós; M. Cos; S. Castañer; A. Pons; M. Gil; A. Fernández-Coello; M. Macià; J. Bruna; C. Aguilera
• Keywords: Chemoradiotherapy; Concomitant; Neurological examination

<h3>BACKGROUND AND PURPOSE:</h3> Current protocols in patients with glioblastoma include performing an MR examination shortly after surgery and then 2–6 weeks ending concomitant chemoradiotherapy. The assessment of this first postradiotherapy is challenging because the pseudoprogression phenomenon may appear. aim study was to explore if before radiation therapy (preradiotherapy imaging) could improve radiologic glioblastoma. <h3>MATERIALS METHODS:</h3> A preradiotherapy imaging prospectively performed start 28 consecutive who had undergone surgical resection. Tumor response chemoradiotherapy assessed twice: early postoperative as baseline baseline. In addition, tumor growth evaluated, its correlation patient survival Kaplan-Meier analysis Cox regression. <h3>RESULTS:</h3> progression found 16 patients, corresponding 7 them (44%). Four assessments switched partial or stable disease when examination, ratio reduced 25% (3 12). Significant differences were stratified according pattern on (median overall "no-growth," 837 days; "focal-growth," 582 "global-growth," 344 <i>P</i> = .001). <h3>CONCLUSIONS:</h3> Performing a clinical management by reducing providing prognostic information.