Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol

• DOI: 10.3174/ajnr.a5748
• Publication Date: 2018-09-06T11:34:41Z
• Authors: J.R. Young; W.B. Pope; M. Bobinski
• Keywords: Dentate nucleus; Deposition

<h3>BACKGROUND AND PURPOSE:</h3> Our aim was to evaluate whether serial administration of the macrocyclic gadolinium-based contrast agent gadoteridol in children is associated with T1-weighted hyperintensity within dentate nucleus, an imaging surrogate for gadolinium deposition. <h3>MATERIALS METHODS:</h3> We identified a retrospective cohort 10 patients younger than 18 years age who underwent between 4 and 8 gadoteridol-enhanced MR examinations brain from 2016 2017. For comparison, we 9 pediatric each 6 gadodiamide-enhanced examinations. examination, both nuclei were contoured on unenhanced images mean dentate-to-pons signal intensity ratio calculated. Dentate-to-pons ratios first last scans compared using paired <i>t</i> tests. <h3>RESULTS:</h3> In group, there no significant change scan (0.99 versus 0.99, <i>P</i> = .59). gadodiamide increase 1.10, .001). <h3>CONCLUSIONS:</h3> Repeat not hyperintensity, while repeat linear presumably due