Brain and Lung Imaging Correlation in Patients with COVID-19: Could the Severity of Lung Disease Reflect the Prevalence of Acute Abnormalities on Neuroimaging? A Global Multicenter Observational Study

• DOI: 10.3174/ajnr.a7072
• Publication Date: 2021-03-11T19:10:18Z
• Authors: A. Mahammedi; A. Ramos; N. Bargalló; M. Gaskill; S. Kapur; L. Saba; H. Carrete; S. Sengupta; E. Salvador; A. Hilario; Y. Revilla; M. Sanchez; M. Perez-Nuñez; S. Bachir; B. Zhang; L. Oleaga; J. Sergio; L. Koren; P. Martin-Medina; L. Wang; M. Benegas; F. Ostos; G. Gonzalez-Ortega; P. Calleja; G. Udstuen; B. Williamson; V. Khandwala; S. Chadalavada; D. Woo; A. Vagal
• Keywords: Adult; Male; SARS-CoV-2; Brain; COVID-19; Neuroimaging; Middle Aged; Magnetic Resonance Imaging; Severity of Illness Index; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Prevalence; Humans; 10. No inequality; Tomography, X-Ray Computed; Lung; Aged; Retrospective Studies

<h3>PURPOSE:</h3> Our aim was to study the association between abnormal findings on chest and brain imaging in patients with coronavirus disease 2019 (COVID-19) neurologic symptoms. <h3>MATERIALS AND METHODS:</h3> In this retrospective, international multicenter study, we reviewed electronic medical records of hospitalized COVID-19 from March 3, 2020, June 25, 2020. inclusion criteria were diagnosed Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) infection acute manifestations available CT imaging. The 5 lobes lungs individually scored a scale 0–5 (0 corresponded no involvement &gt;75% involvement). A lung severity score determined as sum involvement, ranging 0 (no involvement) 25 (maximum <h3>RESULTS:</h3> total 135 met 132 CT, 36 MR imaging, 7 MRA head neck, studies. Compared 86 (64%) without neuroimaging, 49 (36%) these had significantly higher mean (9.9 versus 5.8, <i>P</i> &lt; .001). These more likely present ischemic stroke (40 [82%] 11 [13%], .0001) have either ground-glass opacities or consolidation (46 [94%] 73 [84%], = .01) lungs. threshold &gt;8 found be 74% sensitive 65% specific for neuroimaging. neuroimaging hallmarks infarct (28%), intracranial hemorrhage (10%) including microhemorrhages (19%), leukoencephalopathy and/or restricted diffusion (11%). predominant peripheral consolidation. <h3>CONCLUSIONS:</h3> may predictive abnormalities manifestations. This can used tool patient management improve clinical outcome.