Cholesterol Lowering and Antioxidative Effect of Pregerminated Brown Rice in Hypercholesterolemic Rats

• DOI: 10.3177/jnsv.65.s93
• Publication Date: 2019-10-15T22:15:56Z
• Authors: Marzan SARKAR; Shahdat HOSSAIN; Jakir HUSSAIN; Mahmudul HASAN; Sujan BHOWMICK; Mafroz Ahmed BASUNIA; Michio HASHIMOTO
• Keywords: Lipid peroxide; High-density lipoprotein; Brown rice

Pregerminated brown rice (GBR) is assumed to be more beneficial than polished white (WR), with regard nutrition and cardiovascular health. To support this scientific evidence, cholesterol-lowering antioxidative effects of GBR were studied in the present investigation. The most popular variety Bangladesh BIRI-29 was used prepare WR. Initially, we analyzed proximate composition, phytochemicals, vitro 2, 2-diphenyl-1-picrylhydrazyl (DPPH)-free radical scavenging ability anti-hemolytic GBR. examine dietary impact possible benefits GBR, experimentally-induced hypercholesterolemic (HC, 1% cholesterol) rats fed against WR for 12 wk. At end, plasma total cholesterol (TC), low- high-density lipoprotein-cholesterol (LDL-C HDL-C), triglyceride (TG), fecal TC, hepatic lipid peroxide (LPO) proinflammatory TNFα levels determined. Relative WR, contained higher amounts polyphenols, flavonoids, β-carotene lycopene, exhibited a stronger DPPH-free antihemolytic potentials. Levels LDL-C, TG, TC TG significantly decreased, while HDL-C increased GBR-fed HC-rats, indicating demonstrates antilipidemic effect LPO also decreased (p<0.05) greater extent HC-rats those WR-fed rats. It thus concluded that could natural treatment hypercholesterolemia related risk factors, source antioxidants reduce hemolysis anemia.