Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a

• DOI: 10.3233/cbm-182216
• Publication Date: 2019-03-15T20:19:59Z
• Authors: Shanmei Du; Wei Hu; Yi Zhao; Hengzhong Zhou; Wei Wen; Miao Xu; Peiqing Zhao; Kui Liu
• Keywords: Tensin; Tumor progression

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 breast cancer metastatic In present study, our results showed can inhibit migration invasion cells. addition, an increase microRNA-374a (miR-374a) expression Bioinformatic analysis predicted correlation between miR-374a. Phosphatase tensin homolog (PTEN) was found be novel mRNA target upregulation inhibited progression by decreasing miR-374a enhancing PTEN expression. Together, data revealed is involved cell regulating miR-374a-PTEN axis. These findings offer new insight into treatment strategies for cancer.