Assessment of novel biomarkers: sTREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis

• DOI: 10.3233/npm-180131
• Publication Date: 2019-10-01T18:18:18Z
• Authors: T. Tunç; A. Polat; R. Özdemir; B. Kiliçaslan; E. Can; H.T. Çelik; S. Arsan; Ş Kader; S. Erol; S. Uslu; Ö.M.A. Özdemir; ; B. Özcan; D. Hanta; D. Dilli; F. Narter; N. Gültekin; N. Güzoğlu; Ö. Aydemir
• Keywords: Adrenomedullin; Neonatal Sepsis

BACKGROUND: Early onset bacterial sepsis in neonates (EOS) is recognized as an important health condition. diagnosis crucial. However, blood culture results are released 48–72 hours. Many biomarkers have been investigated but none accepted the gold standard. This study aimed to investigate diagnostic value of molecules: soluble form triggering receptor expressed on myeloid cells-1 (sTREM-1), pentraxin-3 (PTX-3) and pro adrenomedullin (pro-ADM) EOS compare with currently used biomarkers. METHODS: In this multicenter prospective study, patients were enrolled from different NICUs around Turkey. Patient data collected via web-based registry system attending centers. Neonates, hospitalized a suspicion enrolled. Blood routine tests serum sample was obtained kept – 80°C for studying molecules. According laboratory results, divided into three groups as; proven sepsis, clinical control group. Groups compared terms demographic, findings. The primary outcome assess any difference between markers aforementioned. RESULTS: A total 130 enrolled; ( n = 36), 53) 41) groups. similar demographic findings; mean WBC P 0.445), procalcitonin (PCT) 0.083) IL-6 0.814) levels. Mean C-reactive protein (CRP) level significantly higher group < 0.001). PTX-3 0.547), pro-ADM 0.766) sTREM-1 0.838) levels CONCLUSION: These promising molecules failed help early EOS. Their relation correlation disease progression may make more sense they seem be amounts previous studies. CRP most frequently biomarker detecting our population.