Human Leukocyte Antigen-C Genotype and Killer Immunoglobulin-like Receptor-Ligand Matching in Korean Living Donor Liver Transplantation

• DOI: 10.3343/alm.2017.37.1.45
• Publication Date: 2016-11-09T09:36:33Z
• Authors: Hyeyoung Lee; Ki Hyun Park; Hye Sun Park; Ji Hyeong Ryu; Jihyang Lim; Yonggoo Kim; Gun Hyung Na; Dong Goo Kim; Eun-Jee Oh
• Keywords: Adult; Graft Rejection; Male; 0301 basic medicine; Genotype; Graft Survival; Homozygote; HLA-C Antigens; Middle Aged; Ligands; Tissue Donors; Liver Transplantation; 3. Good health; Killer Cells, Natural; 03 medical and health sciences; Asian People; Receptors, KIR; Republic of Korea; Humans; Transplantation, Homologous; Original Article; Female; Alleles; Proportional Hazards Models

The interaction between killer immunoglobulin-like receptors (KIRs) and HLA class I regulates natural (NK) cell cytotoxicity function. impact of NK alloreactivity through KIR in liver transplantation remains unelucidated. Since the frequency HLA-C genotypes show ethnic differences, we assessed HLA-C, genotype, or KIR-ligand mismatch on allograft outcome Korean allografts.One hundred eighty-two living donor transplant patients were studied. Thirty-five (19.2%) had biopsy-confirmed acute rejection (AR), eighteen (9.9%) graft failure. compatibility, genotypes, ligand-ligand, matching was retrospectively investigated for association with outcomes.Homozygous C1 ligands predominant both donors, HLA-C2 allele Koreans lower than that other groups. Despite significantly genotype Koreans, donors at least one showed higher rates AR no alleles (29.2% vs 15.7%, P=0.0423). Although also number activating KIR/inhibitory not associated outcome. expected 31.6% transplants survival.This study could confirm clinical mismatch. However, demonstrated presence influenced allografts.