Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery

• DOI: 10.3345/cep.2019.00913
• Publication Date: 2020-02-05T06:02:51Z
• Authors: Hee Sun Baek; Youngok Lee; Hea Min Jang; Joonyong Cho; Myung Chul Hyun; Yeo Hyang Kim; Su-Kyeong Hwang; Min Hyun Cho
• Keywords: Variation (astronomy)

Acute kidney injury (AKI) is one of the most significant postoperative complications pediatric cardiac surgery. Because serum creatinine has limitations as a diagnostic marker AKI, new biomarkers including neutrophil gelatinase-associated lipocalin (NGAL), molecule-1 (KIM-1), and interleukin-18 (IL-18) are being evaluated to overcome these detect AKI at an early stage after surgery.This study aimed investigate clinical usefulness in young children.Thirty patients with congenital heart diseases who underwent surgery using cardiopulmonary bypass (CPB) were selected, their urine blood samples collected baseline 6, 24, 48 hours Serum urea nitrogen levels well NGAL, KIM-1, IL-18 measured, parameters evaluated.Of 30 patients, 12 developed within In group, 8 (66.6%) met criteria 24 hours, KIM-1/creatinine (Cr) level (with adjustment creatinine) peaked difference from level. Additionally, KIM-1/Cr group was significantly higher than non-AKI 6 hours. However, NGAL/Cr IL-18/Cr showed no specific trend time for surgery.It suggested that concentration could be considered good biomarker prediction open CPB children diseases.