Urinary N-acetyl-β-D-glucosaminidase and Malondialdehyde as a Markers of Renal Damage in Burned Patients

• DOI: 10.3346/jkms.2001.16.5.598
• Publication Date: 2014-09-19T07:28:13Z
• Authors: Hyun Kil Kang; Dong Keon Kim; Bong Hwa Lee; Ae Son Om; Joung Hee Hong; Hyun Chul Koh; Chang Ho Lee; In Chul Shin; Ju Seop Kang
• Keywords: Malondialdehyde; Blood urea nitrogen

This study was aimed to evaluate renal dysfunction during three weeks after the burn injuries in 12 patients admitted Hallym University Hankang Medical Center with flame (total body surface area, 20-40%). Parameters assessed included 24-hr urine volume, blood urea nitrogen, serum creatinine, creatinine clearance, total urinary protein, microalbumin, N-acetyl-beta-D-glucosaminidase (NAG) activity, and malondialdehyde (MDA). Statistical analysis performed using repeated measures ANOVA test. The protein significantly increased on day 3 post-burn fell thereafter. microalbumin excretion showed two peak levels 0 3. NAG activity its maximal level 7 gradually MDA progressively injury. Despite recovery of general function through an intensive care injury, tubular damage lipid peroxidation tissue suggested persist burn. Therefore, a close monitoring management is necessary prevent burn-induced acute failure as well lower mortality major burns.