Abnormal Integrity of Corticocortical Tracts in Mild Cognitive Impairment: A Diffusion Tensor Imaging Study

• DOI: 10.3346/jkms.2008.23.3.477
• Publication Date: 2008-08-01T09:42:31Z
• Authors: Hyun Cho; Dong Won Yang; Young Min Shon; Beum Saeng Kim; Yeong In Kim; Young Bin Choi; Kwang Soo Lee; Yong Soo Shim; Bora Yoon; Woojin Kim; Kook Jin Ahn
• Keywords: Splenium; Inferior longitudinal fasciculus; Fasciculus

Mild cognitive impairment (MCI) has been defined as a transitional state between normal aging and Alzheimer disease. Diffusion tensor imaging (DTI) can estimate the microstructural integrity of white matter tracts in MCI. We evaluated changes MCI patients with DTI. recruited 11 who met working criteria elderly controls. The mean diffusivity (MD) fractional anisotropy (FA) were measured 26 regions brain interest (ROIs) method. In patients, FA values significantly decreased hippocampus, posterior limb internal capsule, splenium corpus callosum, superior inferior longitudinal fasciculus compared to control group. MD increased anterior limbs capsules, right frontal lobe, fasciculus. Microstructural several corticocortical associated cognition identified DTI may be used novel biomarkers for evaluation neurodegenerative disorders.