Cystatin C as an Early Biomarker of Nephropathy in Patients with Type 2 Diabetes

• DOI: 10.3346/jkms.2011.26.2.258
• Publication Date: 2011-01-28T12:39:16Z
• Authors: Yun Kyung Jeon; Mi Ra Kim; Jung Eun Huh; Ji Young Mok; Sang Heon Song; Sang Soo Kim; Bo Hyun Kim; Soo Hyoung Lee; Yong Ki Kim; In Joo Kim
• Keywords: Albuminuria; Microalbuminuria; Cystatin

This study was done to evaluate clinical usefulness of cystatin C levels serum and urine in predicting renal impairment normoalbuminuric patients with type 2 diabetes the association between albuminuria serum/urine C. Type diabetic (n = 332) normoalbuminuria 210), microalbuminuria 83) macroalbuminuria 42) were enrolled. Creatinine, urinary albumin levels, estimated glomerular filtration rate (eGFR by MDRD [Modification Diet Renal Disease] CKD-EPI [Chronic Kidney Disease Epidemiology Collaboration] equations) determined. The increased increasing degree albuminuria, reaching higher macroalbuminuric (P < 0.001). In multiple regression analysis, affected C-reactive protein (CRP), sex, albumin-creatinine ratio (ACR) eGFR. Urine triglyceride, age, eGFR ACR. multivariate logistic identified as independent factors associated 60 mL/min/1.73 m(2) equation normoalbuminuria. On other hand, independently low level high-density lipoprotein patients. could be useful markers for dysfunction