Ceftiaxone-Induced Neurotoxicity: Case Report, Pharmacokinetic Considerations, and Literature Review

• DOI: 10.3346/jkms.2012.27.9.1120
• Publication Date: 2012-08-27T09:50:07Z
• Authors: Ki Bae Kim; Sun Moon Kim; Woori Park; Ji Seon Kim; Soon Kil Kwon; Hye-Young Kim
• Keywords: Neurotoxicity; Discontinuation

Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections.Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported.We report a case acute reversible neurotoxicity associated with ceftriaxone.A 65-yr-old woman chronic kidney disease developed altered consciousness during ceftriaxone urinary tract infection.The electroencephalogram demonstrated continuous bursts generalized, high-voltage, 1 to 2 Hz sharp wave activity.Neurologic symptoms disappeared following withdrawal ceftriaxone.The possibility ceftriaxone-induced should be considered developing neurological impairment use, and discontinuation drug could lead complete improvement.