Feasibility and Safety of Mild Therapeutic Hypothermia in Poor-Grade Subarachnoid Hemorrhage: Prospective Pilot Study

• DOI: 10.3346/jkms.2017.32.8.1337
• Publication Date: 2017-06-30T10:14:49Z
• Authors: Wookjin Choi; Soon Chan Kwon; Won Joo Lee; Young Cheol Weon; Byungho Choi; Hyeji Lee; Eun Suk Park; Ryeok Ahn
• Keywords: Cerebral Vasospasm; Glasgow Outcome Scale

Therapeutic hypothermia (TH) improves the neurological outcome in patients after cardiac arrest and neonatal hypoxic brain injury.We studied safety feasibility of mild TH with poor-grade subarachnoid hemorrhage (SAH) successful treatment.Patients were allocated randomly to either group (34.5°C) or control clipping coil embolization.Eleven received for 48 hours followed by slow rewarming.Vasospasm, delayed cerebral ischemia (DCI), functional outcome, mortality, profiles compared between groups.We enrolled 22 SAH (Hunt & Hess Scale 4, 5 modified Fisher 3, 4).In group, 10 11 (90.9%)patients had a core body temperature < 36°C > 95% 48-hour treatment period.Fewer than (n = 11, each) symptomatic vasospasms (18.1% vs. 36.4%,respectively) DCI (36.3% 45.6%,respectively), but these differences not statistically significant.At 3 months, 54.5% good-to-moderate (0-3 on Rankin [mRS]) 9.0% (P 0.089).Mortality at 1 month was 36.3% 0.0% 0.090).Mild is feasible can be safely used SAH.Additionally, it may reduce risk vasospasm DCI, improving outcomes reducing mortality.A larger randomized controlled trial warranted.