Predicted Impact of the Model for End-Stage Liver Disease 3.0 in a Region Suffering Severe Organ Shortage

• DOI: 10.3346/jkms.2023.38.e274
• Publication Date: 2023-08-16T06:44:01Z
• Authors: Deok-Gie Kim; Seung Hyuk Yim; Eun-Ki Min; Mun Chae Choi; Jae Geun Lee; Myoung Soo Kim; Dong Jin Joo
• Keywords: Liver disease; Economic shortage

The model for end-stage liver disease 3.0 (MELD3.0) is expected to address the flaws of current allocation system deceased donor transplantation (DDLT). We aimed validate MELD3.0 in Korean population where living predominant due organ shortages.Korean large-volume single-centric waitlist data were merged with Network Organ Sharing (KONOS) data. 90-day mortality was compared between MELD and using C-index 2,353 eligible patients registered transplantation. Patient numbers outcomes based on changes KONOS-MELD categorization MELD3.0. Possible gains points reduced analyzed.MELD3.0 performed better than (C-index 0.893 vs. 0.889 MELD). When stratified according categories, 15.9% total 35.2% up-categorized versus categories. mean gain higher women (2.6 ± 2.1) men (2.1 1.9, P < 0.001), severe ascites (3.3 1.8) controls (1.9 1.8, 0.001); however, this trend not significant when score 30. possible increase DDLT chance calculated via up-categorizing MELD3.0, reducible 2.7%.MELD3.0 could predict MELD; merit uncertain, from implementing limited regions suffering shortage, as Korea.