Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma

• DOI: 10.3348/kjr.2015.16.1.125
• Publication Date: 2015-01-15T01:39:52Z
• Authors: Yi-Sheng Liu; Ming-Ching Ou; Yi-Shan Tsai; Xi-Zhang Lin; Chien-Kuo Wang; Hong-Ming Tsai; Ming-Tsung Chuang
• Keywords: Adult; Male; Carcinoma, Hepatocellular; Fever; Intervention; Kaplan-Meier Estimate; Disease-Free Survival; 03 medical and health sciences; Ethiodized Oil; 0302 clinical medicine; Humans; Chemoembolization, Therapeutic; Aged; Drug Carriers; Antibiotics, Antineoplastic; Liver Neoplasms; Middle Aged; Microspheres; Abdominal Pain; 3. Good health; Doxorubicin; Gelatin; Female; Follow-Up Studies

To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB).A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated.No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C was significantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively.In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.