Comparison of Automated Brain Volume Measures by NeuroQuant vs. Freesurfer in Patients with Mild Cognitive Impairment: Effect of Slice Thickness

• DOI: 10.3349/ymj.2021.62.3.255
• Publication Date: 2021-02-24T08:00:37Z
• Authors: Younghee Yim; Ji Young Lee; Se Won Oh; Mi Sun Chung; Ji Eun Park; Yeonsil Moon; Hong Jun Jeon; Won-Jin Moon
• Keywords: Aged, 80 and over; Male; Brain; Reproducibility of Results; Middle Aged; Magnetic Resonance Imaging; Automation; 03 medical and health sciences; Imaging, Three-Dimensional; 0302 clinical medicine; Humans; Original Article; Cognitive Dysfunction; Female; Aged; Retrospective Studies

This study aimed to examine the inter-method reliability and volumetric differences between NeuroQuant (NQ) Freesurfer (FS) using T1 volume imaging sequence with different slice thicknesses in patients mild cognitive impairment (MCI). retrospective enrolled 80 diagnosed MCI at our memory clinic. NQ FS were used for analysis of three-dimensional T1-weighted images thickness 1 1.2 mm. Inter-method was measured Pearson correlation coefficient (r), intraclass (ICC), effect size (ES). Overall, volumes larger than several locations: whole brain (0.78%), cortical gray matter (5.34%), white (2.68%). Volume measures by showed good-to-excellent ICCs both mm (ICC=0.75-0.97, ES=-1.0-0.73 vs. ICC=0.78-0.96, ES=-0.9-0.77, respectively), except putamen, pallidum, thalamus, total intracranial volumes. The all locations, putamen cerebellum, slightly higher a compared those most regions improvement 1-mm thickness. finding indicates that potential effects should be considered when performing measurements impairment.