Relationship between Androgen Deprivation Therapy and Normal-Tension Glaucoma in Patients with Prostate Cancer: A Nationwide Cohort Study

• DOI: 10.3349/ymj.2022.0122
• Publication Date: 2022-09-06T23:57:29Z
• Authors: Jee Soo Ha; Hye Sun Lee; Ju-Young Park; Jinhyung Jeon; Do Kyung Kim; Min Kim; Ho Sik Hwang; Tae Hyo Kim; Hyun Kyu Ahn; Kang Su Cho
• Keywords: Normal tension glaucoma

This study assessed the relationship between newly developed normal-tension glaucoma (NTG) and androgen deprivation therapy (ADT) in patients with prostate cancer.A retrospective population-based cohort was performed. During period 2008 2017, a total of 218203 cancer were identified nationwide claims database Republic Korea. The final analysis included 170874 (42909 ADT group, 127965 control group) after applying inclusion exclusion criteria. incidences NTG according to duration compared controls. Exact matching conducted adjust comorbidities cohorts. Cox proportional hazard regression models performed controlling for latent confounding factors, adjusted ratios (HRs) 95% confidence intervals (CIs) incidence obtained.In matched cohort, group associated significantly reduced risk multivariable group. decreased who underwent less than 2 years (HR=0.824; CI, 0.682-0.995; p=0.0440) those using over (HR=0.796; 0.678-0.934; p=0.0051), controls.Medical castrations results lower diagnosed no ADT. These findings suggest that testosterone may be involved pathogenesis NTG.