Effect of Low Calorie Diet and Controlled Fasting on Insulin Sensitivity and Glucose Metabolism in Obese Patients With Type 1 Diabetes Mellitus

• DOI: 10.33549/physiolres.932381
• Publication Date: 2020-07-09T11:50:03Z
• Authors: F. MUSIL; A. ŠMAHELOVÁ; V. BLÁHA; R. HYŠPLER; A. TICHÁ; J. LESNÁ; Z. ZADÁK; L. SOBOTKA
• Keywords: Glucose clamp technique; Carbohydrate Metabolism; Calorie

Obesity in T1DM patients is associated with the components of metabolic syndrome. The influence controlled fasting and low calorie diet (LCD) on insulin sensitivity glucose metabolism was studied 14 obese type 1 diabetes mellitus (T1DM) (42.6+/-9.4 years, BMI 32.4+/-2.1 kg m(-2)). Insulin measured using a hyperinsulinemic-euglycemic clamp before fasting, immediately after 7 days 21 LCD. Glucose oxidation non-oxidative disposal were during by indirect calorimetry. In control group 13 non-obese (36.9+/-13.9 22.6+/-2.1 m(-2)), only one performed. Obese lost 6.1+/-1.1 maintained reduction body weight Fasting transiently reduced insulin-mediated (from 9.69+/-1.48 to 6.78+/-1.21 mg min(-1) kg(-1), P<0.001). This caused period 2.81+/-0.52 0.88+/-0.98 We conclude that week decreased patients. oxidation.