Statin-Induced Changes in Mitochondrial Respiration in Blood Platelets in Rats and Human With Dyslipidemia

• DOI: 10.33549/physiolres.933264
• Publication Date: 2020-02-28T08:49:23Z
• Authors: J. VEVERA; Z. FIŠAR; T. NEKOVÁŘOVÁ; M. VRABLÍK; L. ZLATOHLÁVEK; J. HROUDOVÁ; N. SINGH; J. RABOCH; K. VALEŠ
• Keywords: Cerivastatin; Cellular respiration; Dyslipidemia

3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used drugs for lowering blood lipid levels and preventing cardiovascular diseases. However, statins can have serious adverse effects, which may be related to development of mitochondrial dysfunctions. The aim study was demonstrate the in vivo effect high therapeutic doses on respiration platelets. Model approach study. Simvastatin administered rats at a dose 4 weeks. Humans were treated with rosuvastatin or atorvastatin 6 Platelet measured using high-resolution respirometry. In rats, significantly lower physiological respiratory rate found intact platelets simvastatin-treated compared controls. humans, no significant changes detected platelets; however, decreased complex I-linked observed after statin treatment permeabilized We propose that small platelet energy metabolism attributed drug effects I electron transport system. Both as readily available biological model cellular patients statins.