Intradialytic Hypotension: Beyond Hemodynamics

• DOI: 10.33549/physiolres.934080
• Publication Date: 2019-11-13T12:16:14Z
• Authors: J. HAJAL; N. JOUBRAN; G. SLEILATY; D. CHACRA; Y. SALIBA; S. ASSAAD; D. CHELALA; N. FARÈS
• Keywords: Endothelial Dysfunction; Plasma renin activity; Pathophysiology

Intradialytic Hypotension is a major complication during hemodialysis session, associated with increased risk of cardiovascular events and mortality. Its pathophysiology believed to be multifactorial remains not well elucidated. The aim this study put forward new mechanisms behind the development intradialytic hypotension. included sixty-five subjects on chronic hemodialysis, divided into two groups: hypotensive (n=12) normotensive (n=53), according variation systolic blood pressure between post-dialysis pre-dialysis measurements. Renin angiotensin converting enzyme I plasma concentrations in both groups but more likely group. Aldosterone concentration group while it decreased hypotension Plasma endothelin showed higher values Post-dialysis asymmetric dimethylarginine 2 were significantly as compared one. Collectrin lower Finally, vascular endothelial growth factor C In conclusion, dysfunction characterized by level vasoactive molecule seems play critical role development.