Linfomatosis cerebral como causa de leucoencefalopatía

• DOI: 10.33588/rn.4611.2007660
• Publication Date: 2019-02-15T07:33:09Z
• Authors: María de Toledo H...; Eva López Valdés; M.Concepción Ferr...; Juan Luís Cervera; Ana Ramos; Ana Cabello Ferná...; Aurelio Hernández...; Santiago Montes-M...; Alfonso Lagares G...; Juan Álvarez-Line...
• Keywords: Brain biopsy; Stereotactic biopsy

Lymphomatosis cerebri (LC) is an infrequent type of primary lymphoma the central nervous system that characterised by diffuse, infiltrating involvement white matter brain without formation a mass.To report case patient with LC in order to draw attention this disease, which rarely diagnosed, and its initial presentation magnetic resonance imaging (MRI) as leukoencephalopathy.Our was 56-year-old female who had clinical signs symptoms sub-acute dementia. Computerised axial tomography MRI head revealed extensive, diffuse bilateral matter, basal nuclei, mesencephalon pons, no mass effect or contrast enhancement. A stereotactic biopsy (which not conclusive) showed perivascular mixed mononuclear-cell inflammatory infiltrate B T cells. No cytologic atypia observed. Treatment established corticoids, produced radiological improvement first two months. During next month underwent rapid deterioration sleepiness worsening ability walk. In scan lesion more heterogeneous appearance on adjacent structures patchy wedge tissue led diagnosis high-grade B-cell lymphoma.The histological may be one typically found lymphomas system, similar other processes involving compromise (cerebral gliomatosis, diseases such Behçet's Sjögren's disease systemic lupus erythematosus).