Development of a Chikungunya Arthritis Disease Activity Score (CHIK-DAS) Based on a Prospective Cohort Study

• DOI: 10.33696/immunology.6.211
• Publication Date: 2025-03-22T09:00:03Z
• Authors: Aileen Yu-hen Chang; Samuel Joseph Sim...; Hugh Watson; Richard L. Amdur; André Siqueira; Abigale Marie Pro...; Sarah Renee Tritsch; Carlos Andres Her...; Liliana Encinales; Alfonso Sucerquia...; Jose Forero-Mejía; Alejandro Jaller; Juan Jose Jaller; J. Kennedy Amaral; Ilana Heckler; Gary Leonard Simon; Larry Moreland; Andres Cadena Bon...; Gary Steven Fires...

Objective: Chikungunya virus is spread by mosquitos and causes a debilitating chronic arthritis that has no standard treatment to date specific measures of disease activity. The objective this expert group was develop measure chikungunya would be useful for clinical trials patient care. Methods: A rheumatologists biostatisticians experienced in the pathological mechanisms evaluated component inclusion activity score (CHIK-DAS). Utilizing data from Colombian cohort 158 patients, linear regression identified components were independently associated with reported outcomes assessing disability, pain, physical mental quality life mobility. preliminary instrument developed using multiple imputation backward selection. Cutoffs grading severity determined. Results: Stiffness, ankle tenderness, 30 tender joint count included 28 joints traditionally Disease Activity Score-28 selected model predicting composite five outcomes. CHIK-DAS scoring formula through weighted combination these variables. In comparison DAS-28, had improved predictive value outcome cutoffs defined remission (<40), mild (40-49.99), moderate (50-59.99) severe (60+) disease. Conclusion: includes DAS-28 addition tenderness stiffness item are prominent arthritis. may used as This metric needs further validation additional cohorts.