Multi-phasic life-threatening anaphylaxis refractory to epinephrine managed by extracorporeal membrane oxygenation (ECMO): A case report

• DOI: 10.3389/falgy.2022.934436
• Publication Date: 2022-07-29T05:32:35Z
• Authors: Juergen Grafeneder; Florian Ettl; Alexandra-Maria W...; Nina Buchtele; Elisabeth Lobmeyr; Thomas Staudinger; Michael Schwameis; Wolfgang R. Sperr; Georg Gelbenegger; Christian Schoerg...; Bernd Jilma
• Keywords: Refractory (planetary science); Rescue therapy; Life saving; Tryptase; Life support

We present a case of 52-year-old patient suffering from multi-phasic life-threatening anaphylaxis refractory to epinephrine treatment. Extracorporeal membrane oxygenation (ECMO) therapy was initiated as the ultima ratio stabilize hemodynamically during episodic severe bronchospasm. ECMO treatment successfully weaned after 4 days. Mastocytosis diagnosed underlying condition. Although is recommended first-line for anaphylaxis, this impressive provides clear evidence its limited therapeutic success and emphasizes need causal therapies.