A Methodology to Compare Biomechanical Simulations With Clinical Brain Imaging Analysis Utilizing Two Blunt Impact Cases

• DOI: 10.3389/fbioe.2021.654677
• Publication Date: 2021-07-01T04:50:03Z
• Authors: X. Gary Tan; Venkata Siva Sai ...; Maria M. D’Souza; Raj K. Gupta; Joseph B. Long; Ajay K. Singh; Amit Bagchi
• Keywords: Modalities; Biomechanics

According to the US Defense and Veterans Brain Injury Center (DVBIC) Centers for Disease Control Prevention (CDC), mild traumatic brain injury (mTBI) is a common form of head injury. Medical imaging data provides clinical insight into tissue damage/injury severity, helps medical diagnosis. Computational modeling simulation can predict biomechanical characteristics such injury, are useful development protective equipment. Integration techniques from computational biomechanics with assessment modalities (e.g., magnetic resonance or MRI) has not yet been used support early diagnosis, assess effectiveness personal This paper presents methodology map simulations interpreting blunt impact TBI utilizing two clinically different case studies. MRI modalities, as T1, T2, diffusion-weighted (DWI) apparent diffusion coefficient (ADC), were comparisons. The cases have reconstructed using finite element analysis based on reports documented by clinician. findings mapped results image-based analyses injuries, that could capture identified. In 1, showed lesions in skull indentation, while 2 had both coup contrecoup sides no deformation. Simulation show measures thresholds needed explain modalities; specifically, strain rate threshold corresponds well minimum pressure coup–contrecoup injury; DWI found be most appropriate modality interpretation. As these substantiated additional studies, this broadly applied tool trauma events improve countermeasures diagnostics equipment design) mitigate injuries.