Sustained Release of VEGF to Promote Angiogenesis and Osteointegration of Three-Dimensional Printed Biomimetic Titanium Alloy Implants

• DOI: 10.3389/fbioe.2021.757767
• Publication Date: 2021-11-15T06:11:28Z
• Authors: Youbin Li; Yuzhe Liu; Haotian Bai; Ronghang Li; Jing Shang; Zhengqing Zhu; Liwei Zhu; Chenyi Zhu; Zhenjia Che; Jincheng Wang; He Liu; Lanfeng Huang
• Keywords: Biocompatibility

Tumor resection and treatment of trauma-related regional large bone defects have major challenges in the field orthopedics. Scaffolds that treat are focus tissue engineering. 3D printing porous titanium alloy scaffolds, prepared via electron beam melting technology, possess customized structure strength. The addition a growth factor coating to scaffold introduces specific form biological activation. Vascular endothelial (VEGF) is key angiogenesis osteogenesis vivo . We designed scaffold/thermosensitive collagen hydrogel system, equipped with VEGF, promote local osseointegration angiogenesis. also verified VEGF release thermosensitive proliferation induction human umbilical vein cells (HUVECs) composite system vitro In , using microscopic computed tomography (Micro-CT), histology, immunohistochemistry analysis, we confirmed aids angiogenesis-mediated regeneration, promotes significantly more integration. discovered has excellent biocompatibility, provides bioactive for osteointegration, an important theoretical basis restoration blood supply strengthening