Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

• DOI: 10.3389/fbioe.2022.874931
• Publication Date: 2022-06-23T08:07:00Z
• Authors: Tao Liu; Zhan Li; Li Zhao; Zehua Chen; Zefeng Lin; Binglin Li; Zhibin Feng; Panshi Jin; Jinwei Zhang; Zugui Wu; Huai Wu; Xuemeng Xu; Xiangling Ye; Ying Zhang
• Keywords: PLGA; Biocompatibility; Bone tissue

Polylactic glycolic acid copolymer (PLGA) has been widely used in tissue engineering due to its good biocompatibility and degradation properties. However, the mismatched mechanical unsatisfactory biological properties of PLGA limit further application bone engineering. Calcium sulfate (CaSO4) is one most promising repair materials non-immunogenicity, well biocompatibility, excellent conductivity. In this study, aiming at shortcomings activity-lack low engineering, customized-designed 3D porous PLGA/CaSO4 scaffolds were prepared by printing. We first studied physical results showed that CaSO4 improved scaffolds. vitro experiments scaffold exhibited biocompatibility. Moreover, addition could significantly improve migration osteogenic differentiation MC3T3-E1 cells scaffolds, made with 20 wt.% best osteogenesis Therefore, calcium was added lead customized printed for enhanced The 3D-printed shows great potential precisely repairing irregular load-bearing defects.