Strategies to improve the therapeutic efficacy of mesenchymal stem cell‐derived extracellular vesicle (MSC-EV): a promising cell-free therapy for liver disease

• DOI: 10.3389/fbioe.2023.1322514
• Publication Date: 2023-12-13T05:08:45Z
• Authors: Lijuan Zheng; Hui Gong; Jing Zhang; Linna Guo; Zhuofan Zhai; Shuang Xia; Zhiyu Hu; Jing Chang; Yizhu Jiang; Xinran Huang; Jingyi Ge; Bikui Zhang; Miao Yan
• Keywords: Liver disease; Extracellular Vesicles; Economic shortage

Liver disease has emerged as a significant worldwide health challenge due to its diverse causative factors and therapeutic complexities. The majority of liver diseases ultimately progress end-stage transplantation remains the only effective therapy with limitations donor organ shortage, lifelong immunosuppressants expensive treatment costs. Numerous pre-clinical studies have revealed that extracellular vesicles released by mesenchymal stem cells (MSC-EV) exhibited considerable potential in treating diseases. Although natural MSC-EV many advantages, some characteristics MSC-EV, such heterogeneity, uneven effect, rapid clearance vivo constrain clinical translation. In recent years, researchers explored plenty ways improve efficacy rotation rate disease. this review, we summarized current strategies enhance potency mainly including optimization culture conditions MSC or modifications aiming facilitate development application