Hydrogel-chitosan and polylactic acid-polycaprolactone bioengineered scaffolds for reconstruction of mandibular defects: a preclinical in vivo study with assessment of translationally relevant aspects

• DOI: 10.3389/fbioe.2024.1353523
• Publication Date: 2024-07-15T05:02:15Z
• Authors: Marco Ferrari; Stefano Taboni; Harley H. L. Chan; Jason Townson; Tommaso Gualtieri; Leonardo Franz; Alessandra Ruaro; Smitha Mathews; Michael J. Daly; Catriona M. Douglas; Donovan Eu; Axel Sahovaler; Nidal Muhanna; Manuela Ventura; Kamol Dey; Stefano Pandini; Chiara Pasini; Federica Re; Simona Bernardi; Katia Bosio; Davide Mattavelli; Francesco Doglietto; Shrinidh Joshi; Ralph W. Gilbert; Piero Nicolai; Sowmya Viswanathan; Luciana Sartore; Domenico Russo; Jonathan C. Irish
• Keywords: Polylactic Acid; Polycaprolactone

Reconstruction of mandibular bone defects is a surgical challenge, and microvascular reconstruction the current gold standard. The field tissue bioengineering has been providing an increasing number alternative strategies for reconstruction.