Unlocking the potential of exosomes: a breakthrough in the theranosis of degenerative orthopaedic diseases

• DOI: 10.3389/fbioe.2024.1377142
• Publication Date: 2024-04-18T14:19:41Z
• Authors: Yaohang Yue; Wei Dai; Yihao Wei; Siyang Cao; Shuai Liao; Aikang Li; Peng Liu; Jianjing Lin; Hui Zeng
• Keywords: osteoarthritis; 0303 health sciences; 03 medical and health sciences; intervertebral disc degeneration; treatment; Bioengineering and Biotechnology; exosomes; osteoporosis; TP248.13-248.65; Biotechnology

Degenerative orthopaedic diseases pose a notable worldwide public health issue attributable to the global aging population. Conventional medical approaches, encompassing physical therapy, pharmaceutical interventions, and surgical methods, face obstacles in halting or reversing degenerative process. In recent times, exosome-based therapy has gained widespread acceptance popularity as an effective treatment for diseases. This therapeutic approach holds potential "cell-free" tissue regeneration. Exosomes, membranous vesicles resulting from fusion of intracellular multivesicles with cell membrane, are released into extracellular matrix. Addressing challenges such rapid elimination natural exosomes vivo limitation drug concentration can be effectively achieved through various strategies, including engineering modification, gene overexpression biomaterial binding. review provides concise overview source, classification, preparation methods exosomes, followed by in-depth analysis their functions applications. Furthermore, explores strategies utilizing diseases, overexpression, The primary objective is provide fresh viewpoint on utilization addressing bone conditions support practical application theranosis