Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool

• DOI: 10.3389/fcell.2014.00029
• Publication Date: 2014-08-07T09:38:52Z
• Authors: Fryad Rahman; Fadi Al Frouh; Benoit Bordignon; Marc Fraterno; Jean-François La...; Franck Peiretti; Michel Fontes
• Keywords: 0301 basic medicine; 571; QH301-705.5; adipocytes; cyclic amp; acide ascorbique; adipocytes; ascorbic acid;cell differentiation; cyclic AMP; Ascorbic Acid; adipocyte; 03 medical and health sciences; Endocrinology; Osteogenesis; Adipocytes; Cyclic AMP; Food and Nutrition; cyclic AMP; Biology (General); différenciation cellulaire; vitamin; adénosine monophosphate cyclique; Cell Differentiation; transducteur; transducer; cell differentiation; [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition; Alimentation et Nutrition; ascorbic acid; lipocytes; [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition

Ascorbic acid (AA) has been considered, for a long time, only as the active principle of vitamin C, with antioxidant properties. We recently demonstrated that ascorbic is competitive inhibitor adenylate cyclases, acting global regulator cAMP pool. It was thus interesting to determine new targets AA, linked its potential signalling capacity, especially during cell differentiation. here AA an preadipocyte lines This inhibition dosage dependent. In addition, we describe impact on expression genes involved in adipogenesis and/or adipocyte phenotype. Moreover, our data suggest treatment partially revert lipids accumulation mature adipocyte. These properties are probably function pool, analogue without properties, same effect. inhibits mesenchyme line, OP9, but drived differentiation this line toward osteogenesis. Finally, intracellular transporter SVCT2 these process and could act receptor.