Mitochondrial Fusion Potentially Regulates a Metabolic Change in Tibetan Chicken Embryonic Brain During Hypoxia

• DOI: 10.3389/fcell.2021.585166
• Publication Date: 2021-02-09T08:11:18Z
• Authors: Qiguo Tang; Cui Ding; Qinqin Xu; Ying Bai; Qiao Xu; Kejun Wang; Meiying Fang
• Keywords: Hypoxia; MFN2; MFN1

The Tibetan chickens ( Gallus gallus ; TBCs) are an indigenous breed found in the Qinghai-Tibet Plateau that well-adapted to a hypoxic environment. As of now, energy metabolism TBCs embryonic brain has been little examined. This study investigated changes during hypoxia, and compared Dwarf Laying Chickens (DLCs), lowland chicken breed, explore underlying mechanisms hypoxia adaptation. We exhibited decreased oxygen consumption rates (OCR) ATP levels as well increased extracellular acidification rate (ECAR) hypoxia. Nevertheless, OCR/ECAR ratios indicated aerobic still dominated under Most important, our results revealed significant differences cellular DLCs Compared DLCs, had higher OCR TCA cycle activities Also, more mitochondrial content, aspect ratio MFN1, MFN2, OPA1 proteins which have previously reported control fusion were expressed at suggesting may regulate by increasing level fusion. In summary, can reduce increase glycolysis enable adaptation Regulation via potentially enhances ability survive on Plateau.