TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma

• DOI: 10.3389/fcell.2021.654407
• Publication Date: 2021-04-30T06:13:24Z
• Authors: Mengqi Gao; Yi Lin; Xing Liu; Zheng Zhao; Zhiyuan Zhu; Hongbo Zhang; Yunchao Ban; Yanan Bie; Xiaozheng He; Xiang Sun; Shizhong Zhang
• Keywords: Isocitrate dehydrogenase

Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma. This study aimed to investigate immune role TERT mutation status which could improve prediction IDHwt. status, IDH mutation, and 1p-19q codeletion data were obtained from 614 glioma cases Cancer Genome Atlas, 325 Chinese Glioma Atlas. The same information was 49 clinical tissues. is preferentially present glioblastoma IDH-wt gliomas associated poor prognosis. Moreover, infiltration neutrophils expression neutrophil chemokines. might partially contribute outcome Furthermore, did not harbor increased peripheral neutrophils, implying that infiltrated tumor environment due cytokine chemotaxis. In this study, we hereby propose be a molecular driver dysfunctional microenvironment may potential therapeutic target for optimizing treatment combinations patient selection immunotherapy.