Senescent Changes and Endoplasmic Reticulum Stress May Be Involved in the Pathogenesis of Missed Miscarriage

• DOI: 10.3389/fcell.2021.656549
• Publication Date: 2021-06-17T08:31:54Z
• Authors: Yunhui Tang; Xinyan Zhang; Yi Zhang; Hua Feng; Jing Gao; Haiyan Liu; Fang Guo; Qi Chen
• Keywords: Senescence

Senescence is involved in many complications of pregnancy. However, whether senescent changes are also associated with missed miscarriage has not been fully investigated.The levels p16, p21, and γH2AX, markers senescence, were measured placentas collected from women by immunohistochemistry Western blotting. Levels misfolded proteins or normal first-trimester placenta that had treated H2O2 (100 μM) extracellular vesicles (EVs) placental explant culture fluorescent compound, thioflavin-T. The production reactive oxygen species (ROS) was CellROX® Deep Red.Increased γH2AX presented compared to controls. Increased shown placentas, but EVs placentas. ROS significantly increased cultures. seen the untreated.Our data demonstrate there increases senescence endoplasmic reticulum stress placenta. Oxidative an accumulation may contribute