Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients

• DOI: 10.3389/fcell.2021.701328
• Publication Date: 2021-06-07T07:20:26Z
• Authors: Ana Cristina Gonç...; Raquel Alves; Inês Baldeiras; Joana Jorge; Bárbara Marques; Artur Paiva; Bárbara Oliveiros; Emília Cortesão; José Manuel Nasci...; Ana Bela Sarmento...
• Keywords: reactive oxygen species; QH301-705.5; myelodysplastic syndrome; 3. Good health; Cell and Developmental Biology; 03 medical and health sciences; 0302 clinical medicine; erythropoiesis-stimulating agents; antioxidant defenses; oxidative stress; response biomarker; Biology (General)

Oxidative stress has been implicated in the development of several types cancer, including myelodysplastic syndromes (MDS), as well resistance to treatment. In this work, we assessed potential oxidative parameters predict response erythropoiesis-stimulating agents (ESAs) lower-risk MDS patients. To end, analyzed systemic levels reactive species (peroxides and NO), antioxidant defenses (uric acid, vitamin E, A, GSH, GSSG, TAS, GPX GR activities], damage (8-OH-dG MDA) 66 patients, from those 44 have treated with ESA. We also calculated peroxides/TAS NO/TAS ratios gene expression redox regulators, NFE2L2 KEAP1. found that patients respond ESA treatment showed lower plasma peroxides ( p < 0.001), cellular GSH activity = 0.001) when compared who did not responders ratio higher than The plasmatic shown be most accurate biomarker response, good sensitivity (80%) specificity (100%) is an independent associated therapy response. Overall, present study demonstrated a correlation between predictive drug (ESA)