B Cell Subset Analysis and Gene Expression Characterization in Mid-Luteal Endometrium

• DOI: 10.3389/fcell.2021.709280
• Publication Date: 2021-08-10T06:39:14Z
• Authors: Mengni Shen; Tim Child; Monica Mittal; Geet Sarodey; Rehan Salim; Ingrid Granne; Jennifer H. South...
• Keywords: Follicular dendritic cells; BCL6; Placentation; CXCR5

The human endometrium is the innermost mucosal membrane of uterus and first point contact for an implanting blastocyst. A wide variety immune cells are found amongst endometrial epithelial layers stromal which both provide host responses against pathogens also assist with placentation pregnancy establishment, however, B have not been characterized, despite being a vital player in adaptive immunity. Through analysis mid-luteal biopsies, we find 1–5% cells, majority were naïve or memory few plasma cells. Compared circulating had activated phenotype, increased expression CD69, HLA-DR, CD74, CD83, IL-10 production capacities. PD1 + CXCR5 ICOS T follicular helper-like FAS IgD – BCL6 germinal center present endometrium, may indicate that playing active role through reactions environment.