Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons

• DOI: 10.3389/fcell.2021.820105
• Publication Date: 2022-02-14T10:02:41Z
• Authors: Markus T. Sainio; Tiina Rasila; Svetlana M. Molch...; Julius Järvilehto; Rubén Torregrosa-...; Sandra Harjuhaahto; Jana Pennonen; Nadine Huber; Sanna-Kaisa Herukka; Annakaisa Haapasalo; Henrik Zetterberg; Tomi Taira; Johanna Palmio; Emil Ylikallio; Henna Tyynismaa
• Keywords: Neurofilament; Axotomy; Axoplasmic transport

Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific intermediate filaments, neurofilaments, which fill axonal cytoplasm, establish caliber growth, and provide structural support. Dominant missense mutations recessive nonsense in neurofilament gene (