The Pyroptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Immunotherapeutic Efficiency in Hepatocellular Carcinoma

• DOI: 10.3389/fcell.2022.779269
• Publication Date: 2022-05-31T10:09:49Z
• Authors: Tao Wang; Yi Yang; Ting Sun; Haizhou Qiu; Jian Wang; Cheng Ding; Ren Lan; Qiang He; Wentao Wang
• Keywords: Pyroptosis; Nomogram

Pyroptosis was recently demonstrated to be an inflammatory form of gasdermin-regulated programmed cell death characterized by cellular lysis and the release several proinflammatory factors participates in tumorigenesis. However, effects pyroptosis-related long noncoding RNAs (lncRNAs) on hepatocellular carcinoma (HCC) have not yet been completely elucidated. Based regression coefficients ZFPM2-AS1, KDM4A-AS1, LUCAT1, NRAV, CRYZL2P-SEC16B, AL031985.3, SNHG4, AL049840.5, AC008549.1, MKLN1-AS, AC099850.3, LINC01224, HCC patients were classified into a low- or high-risk group. The score according lncRNA signature significantly associated with poor overall survival even after adjusting for age clinical stage. Receiver operating characteristic curves principal component analysis further supported accuracy model. Our study revealed that higher risk tumor staging, pathological grade, tumor-node-metastasis stages. nomogram incorporating clinicopathological good accuracy. Furthermore, we observed distinct microenvironment infiltration characteristics between high- low-risk tumors. Notably, based model, found is closely related expression immune checkpoint genes, subtypes tumors, sensitivity chemotherapy drugs immunotherapy. In conclusion, our novel can serve as promising prognostic biomarker provide help guide precision drug treatment