Zfp57 Exerts Maternal and Sexually Dimorphic Effects on Genomic Imprinting

• DOI: 10.3389/fcell.2022.784128
• Publication Date: 2022-02-02T14:01:57Z
• Authors: Zhen Xu; Jiajia Shi; Yu Zhang; Yuhan Liu; Junzheng Zhao; Qian Chen; Chenglin Song; Shuhui Geng; Wei Xie; Feizhen Wu; Yun Bai; Yang Yang; Xiajun Li
• Keywords: Genomic Imprinting; Sexual dimorphism; Imprinting (psychology); Maternal effect

Zfp57 has both maternal and zygotic functions in mouse. It maintains genomic imprinting at most known imprinted regions controls allelic expression of the target genes mouse embryos. The DNA methylation imprint many control (ICRs) is lost when are absent maternal–zygotic mutant Interestingly, we found that a few ICRs was partially without heterozygous embryos derived from homozygous female mice. This suggests essential for maintenance small subset effect applied to switch as well levels corresponding genes. rather surprising affected differently Rasgrf1 AK008011 or male embryos, with more significant loss observed Loss ZFP57 resulted gender-specific differences level changes some These results indicate sexually dimorphic effects on